108 results found
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra et al.
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim et al.
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Developmental Biology

    The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

    Chengdong Liu et al.
    Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca2+]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.
    1. Cell Biology

    Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

    Ryan S D'Souza et al.
    Calcium influx stimulates formation of ER/plasma membrane contacts adjacent to focal adhesions, and lipid transfer at these sites is required for adhesion disassembly during cell migration.
    1. Neuroscience

    Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

    Mirko Luoni et al.
    Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
    1. Cancer Biology
    2. Cell Biology

    Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

    Simranjot Bawa et al.
    TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

    Corinne von Känel et al.
    Mitochondrial inner membrane translocation of presequence-containing proteins by the single bifunctional TIM complex of T. brucei requires an non-canonical J domain-containing protein.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

    Samantha Ebersoll et al.
    African trypanosomes have a trypanothione-based mitochondrial thiol redox metabolism.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li et al.
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.

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