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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
Maia Kinnebrew et al.
The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration
Kuchuan Chen et al.
the loss of Frataxin causes iron accumulation in the nervous system, which in turn enhances sphingolipid synthesis and activation of PDK1 and Mef2, which leads to neurodegeneration.
Microbiology and Infectious Disease
parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate
Natalie A Counihan et al.
Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
Cell type boundaries organize plant development
Monica Pia Caggiano et al.
Leaf position, shape and orientation are pre-patterned by cell type boundaries in the shoot meristem.
Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis
John A Burns et al.
The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth
Bin Qi et al.
The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
Biochemistry and Chemical Biology
Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks
Suwen Zhao et al.
Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.
Abscisic acid dynamics in roots detected with genetically encoded FRET sensors
Alexander M Jones et al.
Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
Genetics and Genomics
celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish
Chunmei Li et al.
The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
Genetics and Genomics
Sex-specific transcriptomic responses to changes in the nutritional environment
M Florencia Camus et al.
Male and female
share core metabolic responses to different nutritional environments, but show opposing patterns of nutrient-dependent reproductive regulation.
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