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    1. Cell Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Cancer Biology
    2. Physics of Living Systems

    Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

    Joshua D Greenlee et al.
    Oxaliplatin-resistant colorectal cancer cells exhibit unregulated death receptor 4 expression with increased receptor palmitoylation and translocation into lipid rafts, increasing their sensitivity to apoptosis via TRAIL.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

    Justyna B Startek et al.
    The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.
    1. Neuroscience

    Female mice ultrasonically interact with males during courtship displays

    Joshua P Neunuebel et al.
    A microphone array enables the vocal contribution of each socially interacting individual to be quantified, and reveals that vocalizations are exchanged between the sexes during mouse courtship.
    1. Cell Biology
    2. Neuroscience

    Free circular introns with an unusual branchpoint in neuronal projections

    Harleen Saini et al.
    A systematic study of RNA localization unexpectedly finds a set of free circular introns with a non-canonical C branchpoint enriched in neuronal projections.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

    Jean-Michel Arbona et al.
    The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
    1. Cell Biology
    2. Developmental Biology

    Apical targeting of the formin Diaphanous in Drosophila tubular epithelia

    Tal Rousso et al.
    Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A subcellular map of the human kinome

    Haitao Zhang et al.
    An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
    1. Cell Biology
    2. Physics of Living Systems

    Centering and symmetry breaking in confined contracting actomyosin networks

    Niv Ierushalmi et al.
    Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.
    1. Cell Biology

    Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

    Ross Nieuwburg et al.
    Dynactin acts as an anti-catastrophe factor that extends microtubule growth; posteriorly elucidating a new essential step in oskar mRNA localisation and providing a novel mechanism by which motor-dependent transport can amplify the polarity of MT networks.