4,111 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto et al.
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

    Gemma LM Fisher et al.
    Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
    1. Cell Biology
    2. Developmental Biology

    Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

    Robert Becker et al.
    Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
    1. Structural Biology and Molecular Biophysics

    Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

    David J Yanofsky et al.
    The structure of the Mycobacterium smegmatis CIII2CIV2 respiratory supercomplex with telacebec (Q203) bound shows how this tuberculosis drug candidate blocks respiration in mycobacteria.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

    Jennifer E Jones et al.
    Phylogenetic relationships between viral RNA segments are distinct between subtypes and lineages of seasonal human influenza A viruses and implicate RNA-RNA relationships as novel drivers of influenza virus evolution.
    1. Neuroscience

    Early life experience sets hard limits on motor learning as evidenced from artificial arm use

    Roni O Maimon-Mor et al.
    Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

    Vinay V Eapen et al.
    A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim et al.
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.

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