1,854 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology

    Xiao Tao, Roderick MacKinnon
    The structure of KvAP addresses a mechanism of voltage-dependent gating that has been debated for 16 years.
    1. Structural Biology and Molecular Biophysics

    The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

    Akira Kawanabe et al.
    Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.
    1. Structural Biology and Molecular Biophysics

    High temperature sensitivity is intrinsic to voltage-gated potassium channels

    Fan Yang, Jie Zheng
    Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.
    1. Structural Biology and Molecular Biophysics

    Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

    Keenan C Taylor et al.
    The intermediate state conformation of the human KCNQ1 potassium channel voltage sensor domain was determined, validated, and shown to be conductive under physiological conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of Eag1 gating by its intracellular domains

    Jonathan R Whicher, Roderick MacKinnon
    Interactions between the voltage sensor and intracellular domains modulate voltage-dependent gating and calmodulin inhibition in the voltage-gated potassium channel Eag1.
    1. Structural Biology and Molecular Biophysics

    Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor

    Pablo Miranda et al.
    Allosteric modulation of BK channels, vital for the physiology of nerve, muscle and endocrine cells, is determined by direct coupling between gating ring RCK1 domains and the voltage sensor function.
    1. Structural Biology and Molecular Biophysics

    Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

    Rizki Tsari Andriani, Yoshihiro Kubo
    A fluorometric analysis under voltage clamp shows the presence of a converged electric field in P2X2 channel with no canonical voltage-sensor and identifies the structural determinants for the voltage-dependent gating.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural determinants of voltage-gating properties in calcium channels

    Monica L Fern√°ndez-Quintero et al.
    Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.
    1. Structural Biology and Molecular Biophysics

    The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel

    Juan Zhao, Rikard Blunck
    Expression of the isolated voltage sensing domain significantly alters its structural conformation as well as its gating kinetics, indicating the importance of studying the biological assembly in its entirety.
    1. Structural Biology and Molecular Biophysics

    Calcium-driven regulation of voltage-sensing domains in BK channels

    Yenisleidy Lorenzo-Ceballos et al.
    Gating currents analysis at different Ca2+ concentrations of BK channels reveals a strong allosteric coupling between Ca2+- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca2+-sites.

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