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Contrary to a generally accepted principle, the pore properties of KCNQ1 channels depend on the states of voltage-sensing domains activation; KCNE1 alters the voltage-sensing domains-pore coupling to modulate KCNQ1 channel properties.

Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.

A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.

Elaborate dendritic branch patterns lead to a local and branch-specific reduction in impedance, which attenuates back-propagating action potentials and limits voltage-gated calcium influx.

Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.

The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.

A combination of high-resolution structure determination, electrophysiology, and MD simulations reveal fundamental insight into the molecular function of voltage-gated chloride channels.

Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.

An atypical neuronal pacemaker mechanism triggers feeding motor pattern in Aplysia..

Experimental measurement of the trajectory of gating charge surrogates during voltage activation and deactivation in a voltage sensor.