A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.

External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.

Sea anemones use adapted ion channels to control stinging behavior.

In vivo analysis of endogenously tagged Ca²⁺ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.

By combining direct presynaptic patch-clamp electrophysiology and super-resolution microscopy, it was found that KO of RIM-BP2 reduced calcium channel abundance in hippocampal mossy terminals.

In the hippocampus, dendritic Na ⁺ spikes are required for signals from the entorhinal cortex to drive action potentials in CA2-but not CA1 or CA3-pyramidal neurons.

Neurexins are essential for shaping the functional properties of glycinergic synapse in the auditory brainstem, further attesting their universal role as critical presynaptic organizers in all major fast chemical synapses.

At distal synapses onto hippocampal CA1 pyramidal neurons, synaptic plasticity is dependent on dendritically initiated sodium spikes, thus establishing a new role for voltage-gated sodium channels in the dendrites that may have important implications for how learning rules are implemented.

Input conveying social novelty information from the hypothalamus controls hippocampal activity by recruiting a novel inhibitory circuit in hippocampal area CA2.

A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.