Xinyi Jenny He, Janki Patel ... Matthew R Banghart
Mu and delta opioid receptors signal independently in hippocampal parvalbumin interneurons to regulate somato-dendritic excitability and synaptic transmission, with the delta opioid receptor dominating the response to enkephalin.
The sour receptor, OTOP1, and related proton channel OTOP3 are steeply activated by extracellular protons while OTOP2 is active over a broad pH range and differences in gating are partly attributed to extracellular domains.
Electrophysiological and optical analysis of neurotransmitter release at central synapses reveals that glutamate signalling is not required for the long-term potentiation (LTP) of presynaptic function, and instead only promotes presynaptic long-term depression (LTD).
Spontaneous fusion of vesicles at synapses is regulated independently of fusion triggered by action potentials, adding to evidence that the two types of fusion have distinct functions.
William F Podlaski, Alexander Seeholzer ... Tim P Vogels
The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.
Simonas Griesius, Amy Richardson, Dimitri Michael Kullmann
NMDA receptors mediate prominent supralinear summation of clustered excitatory inputs to the dendrites of neurogliaform and oriens-lacunosum moleculare interneurons of the hippocampus, showing that these cells perform sub-cellular computations.
Varsha Jain, Benjamin L Murphy-Baum ... Gautam Bhagwan Awatramani
Accurate direction-selective information is present within small sections of the dendrites, raising the possibility that single dendrites utilize parallel processing schemes to process motion information.
David Oestreicher, Shashank Chepurwar ... Tina Pangrsic
Analysis of Cabp1/2 double knockout phyenotype and rescue by viral delivery of Cabp2 identifies the interplay between two CaBPs to promote sustained synaptic transmission at the inner hair cell synapses.
Viktor J Olah, Annie M Goettemoeller ... Matthew JM Rowan
Electrophysiological and genetic analyses reveal a biophysical mechanism in parvalbumin interneurons, uncoupled from changes in gene expression, resulting in reduced cortical inhibition in early-stage Alzheimer's disease.
