Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the Ca_V1.1 calcium channel.

Munc13, a protein that is essential for exocytosis, controls the behavior of voltage gated calcium channels and shapes synaptic plasticity on fast time scales.

Direct patch clamp of ependymal motile cilia reveals that voltage-gated calcium channels in the cell body dominate their electrical and calcium signaling properties.

External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.

Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.

High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.

NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.

A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.

Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.

The small glycine residue in the Cav selectivity filter is an overlooked feature that determines Ca²⁺ selectivity and provides new insight into the Ca²⁺ selectivity mechanism conserved from prokaryotes to eukaryotes.