679 results found
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Probing the force-from-lipid mechanism with synthetic polymers

    Miranda L Jacobs, Jan Steinkühler ... Neha P Kamat
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

    Bhanu Priya Somashekar, Upinder Singh Bhalla
    In feedforward networks with random connectivity, connection motifs underlying the detection of short clusters and activity sequences are likely to converge on a subset of postsynaptic neurons purely by chance.
    1. Cell Biology
    2. Cancer Biology

    Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    Rupinder Singh Jandu, Mohammed Al-Seragi ... Franck Duong van Hoa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    Viktor János Oláh, Jing Wu ... Matthew JM Rowan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Neuroscience

    Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons

    Giulia Di Bartolomei, Raul Ortiz ... Peter Scheiffele
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism

    Susan Lin, Aravind R Gade ... Geoffrey S Pitt
    Variants in FGF13, associated with developmental and epileptic encephalopathies, alter neuronal excitability by affecting inhibitory neurons and by a sodium channel-independent mechanism.
    1. Neuroscience

    An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa V Goodrich
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility

    Genlong Xue, Jiming Yang ... Zhenwei Pan
    lncDACH1 is a novel regulator of sodium channel, which suppresses the membrane trafficking of Nav1.5 by disturbing the function of dystrophin.
    1. Neuroscience
    2. Computational and Systems Biology

    Active dendrites enable robust spiking computations despite timing jitter

    Thomas SJ Burger, Michael E Rule, Timothy O’Leary
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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