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    1. Computational and Systems Biology
    2. Neuroscience

    A taxonomy of seizure dynamotypes

    Maria Luisa Saggio et al.
    Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.
    1. Structural Biology and Molecular Biophysics

    Aromatic interactions with membrane modulate human BK channel activation

    Mahdieh Yazdani et al.
    Computation and experiment together demonstrate that nonspecific membrane–protein interactions could regulate transmembrane protein function and suggest that covalent linkers can be an integral component of the sensing apparatus.
    1. Neuroscience

    Persistent firing in LEC III neurons is differentially modulated by learning and aging

    Carmen Lin et al.
    Temporal associative learning enhances persistent firing in lateral entorhinal cortex (LEC) layer III neurons, while aging decreases persistent firing, leading to cognitive impairments.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger et al.
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez et al.
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
    1. Neuroscience

    Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice

    Li Wang et al.
    Electrical activity at the gonadotropin-releasing hormone (GnRH) neuron cell body and proximal dendrites is not required for the pulsatile secretion of GnRH that controls fertility.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Neuroscience

    Flexible motor sequence generation during stereotyped escape responses

    Yuan Wang et al.
    Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
    1. Neuroscience

    Apical length governs computational diversity of layer 5 pyramidal neurons

    Alessandro R Galloni et al.
    Layer 5 pyramidal neurons vary substantially in dendritic excitability between primary and secondary visual cortex, likely due to a counterintuitive amplifying effect of long apical dendrites.
    1. Neuroscience

    Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages

    Timothy H Murphy et al.
    A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.