807 results found
    1. Structural Biology and Molecular Biophysics

    Cannabidiol interactions with voltage-gated sodium channels

    Lily Goodyer Sait et al.
    The high resolution crystal structure and electrophysiology of a sodium channel complex with cannabidiol, a drug approved for treatment of severe epilepsies, demonstrate the basis for its structural- functional effects.
    1. Structural Biology and Molecular Biophysics

    Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

    Rose E Dixon et al.
    The Ca2+-driven functional coupling of CaV1.2 channels is a mechanism of channel memory that may modulate the amplification of Ca2+ influx.
    1. Neuroscience

    Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

    Hongkang Zhang et al.
    Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.
    1. Structural Biology and Molecular Biophysics

    High temperature sensitivity is intrinsic to voltage-gated potassium channels

    Fan Yang, Jie Zheng
    Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.
    1. Neuroscience

    The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels

    Nathaniel Calloway et al.
    Munc13, a protein that is essential for exocytosis, controls the behavior of voltage gated calcium channels and shapes synaptic plasticity on fast time scales.
    1. Structural Biology and Molecular Biophysics

    Phosphatidic acid modulation of Kv channel voltage sensor function

    Richard K Hite et al.
    Phosphatidic acid influences the gating of voltage-gated K+ channels through a non-specific surface charge mechanism and through a specific interaction between a voltage sensor arginine and the primary phosphate head group on the cytoplasmic membrane leaflet.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of Eag1 gating by its intracellular domains

    Jonathan R Whicher, Roderick MacKinnon
    Interactions between the voltage sensor and intracellular domains modulate voltage-dependent gating and calmodulin inhibition in the voltage-gated potassium channel Eag1.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism

    Ute I Scholl et al.
    A novel Mendelian disease featuring early-onset hypertension is caused by a recurrent gain of function mutation in CACNA1H, which encodes the voltage-gated calcium channel Cav3.2.
    1. Neuroscience

    Voltage-gated Na+ currents in human dorsal root ganglion neurons

    Xiulin Zhang et al.
    Human sensory neurons may not only bridge a critical gap between drug discovery and clinical trials, but force a re-evaluation of basic assumptions about the mechanisms controlling primary afferent excitability.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

    Paul G DeCaen et al.
    Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.

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