1,130 results found
    1. Neuroscience

    A double-sided microscope to realize whole-ganglion imaging of membrane potential in the medicinal leech

    Yusuke Tomina, Daniel A Wagenaar
    For the first time, action potentials and subthreshold postsynaptic potentials of almost all individual identifiable neurons within a functional unit of the leech nervous system were simultaneously imaged during sensory processing and behavioral generation.
    1. Neuroscience

    Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits

    Mária Ashaber et al.
    Voltage-dye imaging followed by serial blockface electron microscopy of the same ganglion reveals structure–function relationships of leech motor behaviors.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Optical estimation of absolute membrane potential using fluorescence lifetime imaging

    Julia R Lazzari-Dean et al.
    Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
    1. Microbiology and Infectious Disease

    Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

    Giancarlo Noe Bruni, Joel M Kralj
    Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
    1. Neuroscience

    Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons

    Yujin Kim et al.
    At distal synapses onto hippocampal CA1 pyramidal neurons, synaptic plasticity is dependent on dendritically initiated sodium spikes, thus establishing a new role for voltage-gated sodium channels in the dendrites that may have important implications for how learning rules are implemented.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

    Mattia Volta et al.
    LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
    1. Structural Biology and Molecular Biophysics

    Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

    Rizki Tsari Andriani, Yoshihiro Kubo
    A fluorometric analysis under voltage clamp shows the presence of a converged electric field in P2X2 channel with no canonical voltage-sensor and identifies the structural determinants for the voltage-dependent gating.
    1. Neuroscience

    Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology

    Joshua H Siegle et al.
    Discrepancies between functional responses measured with electrophysiology and calcium imaging can be largely reconciled by considering the spike-to-calcium transfer function, neuronal sampling bias, and cluster merging artifacts during spike sorting.
    1. Neuroscience

    Dendritic coincidence detection in Purkinje neurons of awake mice

    Christopher J Roome, Bernd Kuhn
    Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.

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