57 results found
    1. Structural Biology and Molecular Biophysics

    Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

    Lining Ju et al.
    New biophysical methods and analyses visualize in real-time a chain of coordinated single-molecular events on a living cell, enabling the inner workings of a mechanoreceptor important to biology to be elucidated.
    1. Microbiology and Infectious Disease
    2. Ecology

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al.
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
    1. Neuroscience

    Odor-identity dependent motor programs underlie behavioral responses to odors

    Seung-Hye Jung et al.
    Flies respond to odors by modulating multiple independently modulated motor programs.
    1. Neuroscience

    PARIS, an optogenetic method for functionally mapping gap junctions

    Ling Wu et al.
    As the first fully genetically encoded method, PARIS allows cell-specific, long-term, repeated measurements of gap junctional coupling with high spatiotemporal resolution, facilitating its study in both health and disease.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Motility precedes egress of malaria parasites from oocysts

    Dennis Klug, Friedrich Frischknecht
    A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.
    1. Human Biology and Medicine
    2. Neuroscience

    Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    Jerome Robert et al.
    Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Work minimization accounts for footfall phasing in slow quadrupedal gaits

    James R Usherwood, Zoe T Self Davies
    The range of footfall patterns seen in walking amphibians, reptiles and mammals, including hippopotamus, horse and (inverted) sloth, are consistent with simple principles of mechanical work minimization.
    1. Neuroscience

    Functional integration of a serotonergic neuron in the Drosophila antennal lobe

    Xiaonan Zhang, Quentin Gaudry
    Serotonergic cells innervating the Drosophila antennal lobe are inhibited by odors and modulate olfactory responses in conjunction with the entire serotonergic network.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.

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