New biophysical methods and analyses visualize in real-time a chain of coordinated single-molecular events on a living cell, enabling the inner workings of a mechanoreceptor important to biology to be elucidated.
The range of footfall patterns seen in walking amphibians, reptiles and mammals, including hippopotamus, horse and (inverted) sloth, are consistent with simple principles of mechanical work minimization.
Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.
Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
Multimodal neuroimaging was used to study the effect of threat on spontaneous brain activity and functional connectivity, and demonstrated that threat increases both activity and connectivity of the intraparietal sulcus, a key node in the frontoparietal attention network.