101 results found
    1. Developmental Biology

    A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in Caenorhabditis elegans

    Jennifer D Cohen et al.
    Confocal imaging, electron microscopy, and genetic perturbations provide an unprecedented view of a complex and dynamic luminal matrix that determines tube shape during morphogenesis.
    1. Developmental Biology
    2. Physics of Living Systems

    Gene-free methodology for cell fate dynamics during development

    Francis Corson, Eric D Siggia
    Mathematical methods based on geometry that directly embody the developmental concepts of competency, commitment, and determination provide succinct descriptions of morphogenesis and allow quantitative predictions from fits to sparse genetic data in Caenorhabditis elegans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A broad mutational target explains a fast rate of phenotypic evolution

    Fabrice Besnard et al.
    A broad mutational target is the cause of the high mutational variance and corresponding fast phenotypic evolutionary rate in P3.p cell fate in Caenorhabditis nematodes.
    1. Cell Biology

    Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling

    Shelly TH McClatchey et al.
    A Notch-mediated signaling pathway upregulates a Sec14-GOLD phosphopholipid binding protein that promotes a morphogenetic process important in tissue remodeling and renewal.
    1. Neuroscience

    Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition

    Kevin M Collins et al.
    The neural circuit that regulates egg-laying behavior in nematode worms is activated by egg production, coupled to the circuit that generates movement, and inhibited by sensory feedback from egg release.
    1. Ecology
    2. Evolutionary Biology

    Molecular basis of wax-based color change and UV reflection in dragonflies

    Ryo Futahashi et al.
    UV-reflective dragonfly wax is shown to consist of very long-chain methyl ketones and aldehydes, and a synthetic dragonfly wax spontaneously forms light-scattering fine structures with strong UV reflection.
    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li et al.
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Cell Biology
    2. Developmental Biology

    The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells

    Andrea Haag et al.
    The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in Caenorhabditis elegans and in human cells.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
    1. Cell Biology

    Metformin extends C. elegans lifespan through lysosomal pathway

    Jie Chen et al.
    Metformin extends C. elegans lifespan through lysosome-dependent coordination of TORC1 and AMPK pathways.

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