4,740 results found
    1. Evolutionary Biology

    A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.
    1. Evolutionary Biology

    Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs

    Michelle C Ward, Siming Zhao ... Yoav Gilad
    Human and chimpanzee-induced pluripotent stem cells show limited species-specificity in transposable element silencing.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward, Nicholas E Banovich ... Yoav Gilad
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants

    Carlos Martinez-Ruiz, Rodrigo Pracana ... Yannick Wurm
    Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.
    1. Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo, James S Ware ... Raúl Padrón
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.
    1. Structural Biology and Molecular Biophysics

    Structure of the bacterial ribosome at 2 Å resolution

    Zoe L Watson, Fred R Ward ... Jamie HD Cate
    High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
    1. Structural Biology and Molecular Biophysics

    Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli

    Sebastian Jojoa-Cruz, Adrienne E Dubin ... Andrew B Ward
    Structural comparison and electrophysiology of OSCA channels shed light on potential structural features influencing response to poke stimulus.
    1. Ecology
    2. Evolutionary Biology

    Thermal phenotypic plasticity of pre- and post-copulatory male harm buffers sexual conflict in wild Drosophila melanogaster

    Claudia Londoño-Nieto, Roberto García-Roa ... Pau Carazo
    Natural temperature variation across an optimal reproductive range for wild flies (Drosophila melanogaster) modulates the impact of sexual conflict on female fitness via asymmetric effects on pre- and post-copulatory male harm mechanisms.
    1. Neuroscience

    Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans

    Andrés Vidal-Gadea, Kristi Ward ... Jonathan Pierce-Shimomura
    With the aid of a pair of sensory neurons, the nematode worm C. elegans is able to detect the Earth's magnetic field and use it to navigate towards food sources.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the mechanically activated ion channel OSCA1.2

    Sebastian Jojoa-Cruz, Kei Saotome ... Andrew B Ward
    Structures of OSCA1.2, a member of a newly characterized family of mechanically activated ion channels, provide insights into mechanism of channel gating by membrane tension.

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