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    1. Neuroscience

    Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

    Katherine Cora Ames, Mark M Churchland
    Neurons in motor cortex contain information about each arm, but these signals are separated into different dimensions, allowing separate control of each arm.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical design principles of a mitotic spindle

    Jonathan J Ward, Hélio Roque ... François Nédélec
    Precise control of microtubule architecture greatly increases the force that the spindle can exert on chromosomes.
    1. Neuroscience

    Early life experience sets hard limits on motor learning as evidenced from artificial arm use

    Roni O Maimon-Mor, Hunter R Schone ... Tamar R Makin
    Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
    1. Neuroscience

    Area 2 of primary somatosensory cortex encodes kinematics of the whole arm

    Raeed H Chowdhury, Joshua I Glaser, Lee E Miller
    Area 2 of somatosensory cortex represents kinematic details of the entire arm during movement, but this mapping from limb state to neural activity differs for reaching and passive limb displacement.
    1. Neuroscience

    Postural control of arm and fingers through integration of movement commands

    Scott T Albert, Alkis M Hadjiosif ... Reza Shadmehr
    After a movement, the final posture of the arm is stabilized by a subcortical structure that mathematically integrates movement commands over time.
    1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward
    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan, Scott A Chisholm ... Tania F de Koning-Ward
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Computational and Systems Biology
    2. Neuroscience

    The energetic basis for smooth human arm movements

    Jeremy D Wong, Tyler Cluff, Arthur D Kuo
    An energetic cost related to force rate is quantified in human arm movements, and minimizing this cost predicts smoothness without minimizing variance, unifies motor-planning of smoothness and movement duration, and may help resolve motor redundancies.
    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li, Kevin M Collins ... Kang Shen
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

    Mark David Hayes, Sophie Ward ... Jessica Strid
    Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.