4,464 results found
    1. Neuroscience

    Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1

    Terri M Driessen et al.
    Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.
    1. Neuroscience

    Sucrose intensity coding and decision-making in rat gustatory cortices

    Esmeralda Fonseca et al.
    The neural representation of perceived sucrose intensity was contained in the firing rate and spike-timing of a 'small' population of neurons distributed across the Insula and Orbitofrontal taste cortices.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

    Colin D Meiklejohn et al.
    Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
    1. Cell Biology

    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

    Sam A Menzies et al.
    CRISPR/Cas9 genome-wide screens using sterol-sensitive endogenous HMG-CoA reductase (HMGCR) reporter identify the sterol-responsive RNF145 and gp78 as independently responsible for sterol-accelerated degradation of HMGCR, the rate-limiting enzyme of cholesterol biosynthesis.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Microbiology and Infectious Disease

    Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

    Siyuan Ding et al.
    Rotavirus infection induces phosphorylation and proteasomal degradation of MAVS to suppress host antiviral interferon signaling.
    1. Cancer Biology

    Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Biochemistry and Chemical Biology

    SETD3 protein is the actin-specific histidine N-methyltransferase

    Sebastian Kwiatkowski et al.
    Histone-lysine N-methyltransferase SETD3 (NP_115609.2) was identified as the actin-specific histidine N-methyltransferase, an enzyme catalyzing the extremely well-conserved methylation of H73 in β-actin.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Tau monomer encodes strains

    Apurwa M Sharma et al.
    Tau monomer from aggregate-containing cell models and tauopathy brains adopts discrete structures that act as templates, dictating the conformation of distinct strains that result from its seeding activity.
    1. Neuroscience

    Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome

    Anton Miroschnikow et al.
    A parallel neuronal network architecture ensures control of basic feeding reflex circuits via integration of crossmodal sensory information to filter multiple biological events and enhance meaningful behavioral choice.

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