7,545 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

    Nicholas R Ader et al.
    Correlative microscopy and electron cryo-tomography on apoptotic HeLa cells reveal remodeling of outer and inner mitochondrial membranes, Bax cluster ultrastructure and ATP synthase reorganization in ruptured mitochondria.
    1. Ecology
    2. Evolutionary Biology

    Molecular basis of wax-based color change and UV reflection in dragonflies

    Ryo Futahashi et al.
    UV-reflective dragonfly wax is shown to consist of very long-chain methyl ketones and aldehydes, and a synthetic dragonfly wax spontaneously forms light-scattering fine structures with strong UV reflection.
    1. Cell Biology

    Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

    Jason Karch et al.
    The proteins Bax and Bak, which increase the permeability of the mitochondrial membrane during apoptosis, are also crucial for generating a mitochondrial membrane pore that is specifically involved in necrosis.
    1. Developmental Biology

    Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

    Jason Karch et al.
    Molecular pathways controlling autophagic cell death are regulated at the level of the lysosome through the activity of the pro-death Bcl-2 family member Bax/Bak.
    1. Cell Biology
    2. Developmental Biology

    Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

    Max Werth et al.
    A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.
    1. Immunology and Inflammation

    T cell immunodominance is dictated by the positively selecting self-peptide

    Wan-Lin Lo et al.
    The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
    1. Neuroscience

    Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation

    Sagi Jaffe-Dax et al.
    Implicit memory traces for recently encountered perceptual stimuli, including words, decay more quickly in people with dyslexia.
    1. Chromosomes and Gene Expression

    Nucleosomes impede Cas9 access to DNA in vivo and in vitro

    Max A Horlbeck et al.
    Nucleosomes provide a direct and profound block to the activity of the CRISPR effector protein Cas9, suggesting future sophisticated design rules for CRISPR targeting.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan et al.
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    1. Neuroscience

    Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

    Guoqiang Wan et al.
    Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.

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