18,160 results found
    1. Genetics and Genomics
    2. Neuroscience

    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

    Caryn R Hale, Kirsty Sawicka ... Robert B Darnell
    Combining compartment- and cell-type specific transcriptomic approaches reveals FMRP regulation of synaptic regulators in the dendrites and chromatin regulators in the cell bodies of CA1 neurons.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele, Daniel M Whalen ... Rajat Rohatgi
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
    1. Ecology

    Vessel noise levels drive behavioural responses of humpback whales with implications for whale-watching

    Kate R Sprogis, Simone Videsen, Peter T Madsen
    Controlled exposure experiments reveal that underwater vessel noise level from a motorised vessel is an adequate driver of behavioural disturbance in humpback whales.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    The biological function of an insect antifreeze protein simulated by molecular dynamics

    Michael J Kuiper, Craig J Morton ... Angus Gray-Weale
    Simulations of the biological function of an antifreeze protein reveal its molecular interactions with the ice/water interface.
    1. Evolutionary Biology
    2. Neuroscience

    Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human

    Petra Wahle, Eric Sobierajski ... Gundela Meyer
    Archived histological material from tracing studies, immunohistochemistry, and Golgi impregnations allowed to discover a so far unrecognized structural difference, potentially of functional importance, between neocortical pyramidal neurons of rodent, carnivore, and ungulate as compared to monkey and man.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Ecology

    Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

    Heather Vance, Peter T Madsen ... Mark Johnson
    Echolocating toothed whales can detect and react to sudden prey movements during close approaches with speeds similar to ultra-fast tracking responses in human vision.
    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding, Daniel J Vanselow ... Keith C Cheng
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Ecology
    2. Evolutionary Biology

    Fin whale song evolution in the North Atlantic

    Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
    The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
    1. Neuroscience

    Model-based whole-brain perturbational landscape of neurodegenerative diseases

    Yonatan Sanz Perl, Sol Fittipaldi ... Enzo Tagliazucchi
    The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response.

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