3,791 results found
    1. Developmental Biology
    2. Neuroscience

    Transverse sinus injections drive robust whole-brain expression of transgenes

    Ali S Hamodi et al.
    A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren et al.
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Neuroscience

    The expression of established cognitive brain states stabilizes with working memory development

    David Florentino Montez et al.
    The excessive behavioral variability associated with adolescence is the result of greater instability of widespread or global gain signals which produces greater variability in the amplitude of expression of whole-brain states of task-related activity.
    1. Neuroscience

    Elevating acetyl-CoA levels reduces aspects of brain aging

    Antonio Currais et al.
    A novel neuroprotective pathway that enhances acetyl-CoA metabolism via inhibition of acetyl-CoA carboxylase 1 may prevent the contribution of the aging process in the brain to Alzheimer's disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
    1. Cancer Biology
    2. Computational and Systems Biology

    5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA

    Marketa Tomkova et al.
    Different types of epigenetic DNA modifications affect the likelihood of cytosine mutations in cancer.
    1. Microbiology and Infectious Disease

    Robust manipulation of the behavior of Drosophila melanogaster by a fungal pathogen in the laboratory

    Carolyn Elya et al.
    A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown et al.
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Chromosomes and Gene Expression

    Enhancer regions show high histone H3.3 turnover that changes during differentiation

    Aimee M Deaton et al.
    Nucleosomes at enhancers are unusually dynamic and change histone turnover rates during differentiation.

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