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    1. Computational and Systems Biology
    2. Developmental Biology

    Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain

    David M Young, Siavash Fazel Darbandi ... Stephan J Sanders
    A computational tool developed to construct three-dimensional anatomical atlases from two-dimensional data generates volumetrically complete and aligned atlases for all stages of development in the Allen Developing Mouse Brain Atlas.
    1. Neuroscience

    Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age

    Simone Kühn, Anna Mascharek ... IMAGEN Consortium
    Trajectories of adolescent drinking behavior between age 14 and 19 years can be predicted from bilateral striatal and cerebellar grey matter at 14 years of age.
    1. Neuroscience

    In situ X-ray-assisted electron microscopy staining for large biological samples

    Sebastian Ströh, Eric W Hammerschmith ... Adrian Andreas Wanner
    In situ X-ray imaging of biological tissue samples in staining solution while they are being processed for electron microscopy reveals novel insights into the diffusion-reaction kinetics, tissue mechanics, and staining quality.
    1. Cell Biology
    2. Neuroscience

    Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

    Wei Jiao, Gard Spreemann ... Brian D McCabe
    Fewer neurons and more glia than previously predicted plus substantial differences between males and females are revealed when entire intact Drosophila larval central nervous systems are quantified using a synthesis of genetic, imaging, and computation technologies.
    1. Neuroscience

    A task-general connectivity model reveals variation in convergence of cortical inputs to functional regions of the cerebellum

    Maedbh King, Ladan Shahshahani ... Jörn Diedrichsen
    Models of cortico-cerebellar connectivity are quantified using task-based fMRI, and demonstrate that convergent rather than sparse inputs best characterize cortico-cerebellar connectivity, namely, cerebellar areas linked to cognition receive the highest convergence of cortical inputs.
    1. Neuroscience

    Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

    Hyun Jee Lee, Jingting Liang ... Hang Lu
    Highly accurate automated cell annotation in multi-cell imaging enables cell identification and reduces subjectivity in Caenorhabditis elegans neural image processing.
    1. Neuroscience

    A double-sided microscope to realize whole-ganglion imaging of membrane potential in the medicinal leech

    Yusuke Tomina, Daniel A Wagenaar
    For the first time, action potentials and subthreshold postsynaptic potentials of almost all individual identifiable neurons within a functional unit of the leech nervous system were simultaneously imaged during sensory processing and behavioral generation.
    1. Neuroscience

    EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

    Petteri Stenroos, Isabelle Guillemain ... Emmanuel L Barbier
    Rats with absence epilepsy exhibit hindered and restricted sensory processing during ongoing seizures, as demonstrated by functional magnetic resonance imaging and mean-field simulation studies.
    1. Computational and Systems Biology
    2. Neuroscience

    Characterizing functional pathways of the human olfactory system

    Guangyu Zhou, Gregory Lane ... Christina Zelano
    Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.
    1. Neuroscience

    Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues

    Kevin Vinberg, Jörgen Rosén ... Fredrik Ahs
    A whole brain analysis using human neuroimaging data shows neural correlates of individual differences in conditioned fear.