835 results found
    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia et al.
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Microbiology and Infectious Disease

    Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

    Jun Kurushima et al.
    DNA uptake and recombination in pneumococcus are highly efficient and independent of the cell-cycle or genetic location of the transformed allele, but limited to maximally 50% of the population.
    1. Structural Biology and Molecular Biophysics

    Structure of the bacterial ribosome at 2 Å resolution

    Zoe L Watson et al.
    High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
    1. Neuroscience

    AANAT1 functions in astrocytes to regulate sleep homeostasis

    Sejal Davla et al.
    Drosophila astrocytes regulate the homeostatic response to sleep need and express the AANAT1 enzyme that limits brain accumulation of serotonin and dopamine caused by overnight sleep deprivation.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen et al.
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Cancer Biology
    2. Cell Biology

    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

    Yen-Lin Huang et al.
    Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
    1. Microbiology and Infectious Disease

    Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

    Sebastian Felgner et al.
    Upon host cell contact, motile but not non-motile Pseudomonas aeruginosa exhibit a change in their gene expression program that includes the expression of spermidine, which triggers motility-dependent phagocytosis.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi et al.
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.

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