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In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.

Ded1p and eIF4A, two RNA helicases that function in eukaryotic translation initiation, interact physically with each other and with the scaffolding protein eIF4G.

Statistical learning shapes pain perception by allowing the brain to predict and modulate pain intensity based on temporal patterns, providing insights into pain regulation and their relevance to chronic pain.

Yap and Taz regulate proliferation and differentiation of Schwann cells, driving radial sorting, myelination and myelin maintenance of peripheral nerves.

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.

Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.

Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.

Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.

A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.