3 results found
    1. Chromosomes and Gene Expression

    Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse

    Luke Isbel, Lexie Prokopuk ... Emma Whitelaw
    Though generally considered a transcriptional repressor, Wiz may also function as a transcriptional activator in the mouse brain and is required for normal behaviour.
    1. Developmental Biology

    Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice

    Shinichiro Hayashi, Ichiro Manabe ... Yumiko Oishi
    The regulatory programs governing skeletal muscle regeneration that are controlled by Klf5 in cooperation with MyoD and Mef2 provide a potential avenue for intervention into muscle regeneration through modulation of Klf5.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.

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