Intramembrane proteases identify target proteins in a different way from other proteases.

The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.

A transmembrane protein uses distinct mechanisms to regulate the movement of specific toll-like receptors-key immune system components involved in detecting pathogens-to their final locations inside cells.

A gene that codes for a transcription factor that is involved in lipid and carbohydrate metabolism also has a role in the regulation of circadian rhythms.

Ubiquitin ligase adaptors target the selective clearance of misfolded plasma membrane proteins.

Experiments on synthetic models of synaptic vesicles have shed new light on the role of the protein α-synuclein in the central nervous system.

The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.

Computer simulations reveal that viral nucleic acids have an ideal structure for being packaged into outer protein shells called capsids.

In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.