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    1. Neuroscience

    FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

    Kirsty Sawicka, Caryn R Hale ... Robert B Darnell
    Identifying FMRP-bound mRNAs in hippocampal CA1 pyramidal neurons reveals cell-type specific regulation of autism-candidate and circadian mRNAs and FMRP-mediated control of memory across the circadian cycle.
    1. Neuroscience

    Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors

    Flavia P Franco, Pingxi Xu ... Walter S Leal
    The southern house mosquito senses the oviposition attractants skatole and indole with two receptor proteins sharing only 50% amino acid identity, and having the residues alanine-73 and leucine-74 in the skatole and indole receptors, respectively, control their specificity.
    1. Neuroscience

    Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

    Erin A Clark, Michael Rutlin ... Sacha B Nelson
    RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang, Anita Pottekat ... Randal J Kaufman
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Neuroscience

    Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons

    Darya Task, Chun-Chieh Lin ... Christopher J Potter
    Olfactory neurons of insects, once thought to express only a single type of olfactory receptor, exhibit widespread co-expression of receptors from multiple chemosensory gene families.
    1. Plant Biology

    The chloroplast 2-cysteine peroxiredoxin functions as thioredoxin oxidase in redox regulation of chloroplast metabolism

    Mohamad-Javad Vaseghi, Kamel Chibani ... Karl-Josef Dietz
    The chloroplast 2-cysteine peroxiredoxin is central player and missing link in the chloroplast thiol-disulfide redox regulatory network, and participates in oxidative inactivation of reductively activated enzymes in photosynthesis.
    1. Developmental Biology
    2. Neuroscience

    Cd59 and inflammation regulate Schwann cell development

    Ashtyn T Wiltbank, Emma R Steinson ... Sarah Kucenas
    Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
    1. Evolutionary Biology

    Colour polymorphism associated with a gene duplication in male wood tiger moths

    Melanie N Brien, Anna Orteu ... Johanna Mappes
    A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.
    1. Neuroscience

    Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

    Charanya Sampathkumar, Yuan-Ju Wu ... Christian Rosenmund
    In mouse models of Rett syndrome, the impaired cell autonomous BDNF feed forward signaling pathway results in abnormalities in neurite outgrowth and synapse formation in excitatory neurons.
    1. Neuroscience

    Shank3 modulates sleep and expression of circadian transcription factors

    Ashley M Ingiosi, Hannah Schoch ... Lucia Peixoto
    Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.