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    1. Neuroscience

    Cortical encoding of acoustic and linguistic rhythms in spoken narratives

    Cheng Luo, Nai Ding
    In the processing of spoken narratives, bottom-up acoustic cues and top-down linguistic knowledge separately contribute to neural construction of linguistic units.
    1. Cell Biology

    A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

    Wenmin Xing et al.
    Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
    1. Evolutionary Biology

    Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

    Tianming Wang et al.
    Identification and functional characterization of the first non-chordate kisspeptin neuropeptide system in the sea cucumber indicates the ancient origin of the intracellular signaling and physiological functions of this molecular system.
    1. Structural Biology and Molecular Biophysics

    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

    Lan Wang et al.
    Msp1 recruits substrates at the open seam of the spiral oligomer and extracts them with functionally adapted elements.
    1. Developmental Biology
    2. Neuroscience

    Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

    Yanshu Wang et al.
    Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips et al.
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.
    1. Cell Biology

    Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction

    Junqi Huang et al.
    Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

    Doudou Wang et al.
    The structural and functional analysis demonstrates the mechanism of dual functional, motility and microtubule depolymerization in a unique motor, KIF19A.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ring-like oligomers of Synaptotagmins and related C2 domain proteins

    Maria N Zanetti et al.
    A model for synchronous neurotransmitter release suggests that when not in the presence of calcium ions, Synaptotagmin proteins form ring-like structures between the vesicle and plasma membrane that prevent spontaneous fusion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

    Spencer Hill et al.
    Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.