Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
Identification and functional characterization of the first non-chordate kisspeptin neuropeptide system in the sea cucumber indicates the ancient origin of the intracellular signaling and physiological functions of this molecular system.
Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
A model for synchronous neurotransmitter release suggests that when not in the presence of calcium ions, Synaptotagmin proteins form ring-like structures between the vesicle and plasma membrane that prevent spontaneous fusion.
Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.