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    1. Developmental Biology

    Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

    Marketa Kaucka et al.
    The brain and olfactory epithelium play a key role in pattering chondrogenic areas in the developing face, which is partly based on the release of SHH from neurosensory structures into the facial mesenchyme.
    1. Cancer Biology

    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

    Krystal Ann Orlando et al.
    BRG1 loss drives initiation and progression in human cancers through changes in specific differentiation programs in an AP-1-dependent manner.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

    Thomas W Bebee et al.
    Large-scale developmental defects in mice occur with the ablation of the epithelial-specific splicing factors Esrp1 and Esrp2.
    1. Cell Biology
    2. Computational and Systems Biology

    TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

    Raphaël Etournay et al.
    A computational framework called TissueMiner, complete with tutorials, will allow a wide range of users to perform quantitative multiscale analysis of tissue morphogenesis.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection

    Balaji Banoth et al.
    The integration of signals via the pleiotropic NF-kappaB (NF-κB) system enables microenvironmental cues to tune cellular responses to pathogenic substances.
    1. Cell Biology
    2. Developmental Biology

    Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

    Alexander D Fulford et al.
    The tissue growth controlling Hippo signalling pathway is modulated by the activity of the Casein Kinase 1 family, which regulates the protein stability of the upstream Hippo pathway component Expanded.
    1. Cell Biology
    2. Developmental Biology

    Microtubules provide directional information for core PCP function

    Maja Matis et al.
    The Fat/Dachsous/Four-jointed (Ft/Ds/Fj) system provides a spatial signal to organize core PCP proteins via the polarization of microtubules.
    1. Physics of Living Systems

    Epithelial colonies in vitro elongate through collective effects

    Jordi Comelles et al.
    Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang et al.
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Cell Biology

    Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

    Kalyn Kono et al.
    Par-complex-dependent cell polarity can be cell-autonomously conferred to non-polar Drosophila S2 cells, unveiling temporal patterns toward the cortical localization of Par-complex aggregates that include a meshwork containing unit segments.