13,618 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen, Deyang Xu ... Barbara Ann Halkier
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Ecology

    Parental effects alter the adaptive value of an adult behavioural trait

    Rebecca M Kilner, Giuseppe Boncoraglio ... Hanna Kokko
    The adaptive value of social behaviour exhibited in adult life varies with conditions experienced in early life, and poorer conditions may promote conflict over cooperation.
    1. Developmental Biology
    2. Plant Biology

    Cross-species functional diversity within the PIN auxin efflux protein family

    Devin Lee O'Connor, Samuel Elton ... Ottoline Leyser
    Comparative genetics between distant plant species shows that for the PIN auxin transport proteins differential membrane and tissue-level accumulation, transport activity, and interaction result in different functional properties in the shoot post transcription.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

    Aarya Venkat, Grace Watterson ... Natarajan Kannan
    Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.
    1. Stem Cells and Regenerative Medicine

    HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

    Tamar Tak, Giulio Prevedello ... Leïla Perié
    Hematopoietic stem and progenitor cells are heterogeneous on a population level, while cells derived from a common ancestor have similar division and differentiation patterns, indicating priming towards a certain differentiation/division fate.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

    Paul G DeCaen, Yuka Takahashi ... David E Clapham
    Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study

    Laurence J Howe, Ben Brumpton ... Neil M Davies
    Genetic data from siblings provides strong evidence that taller height increases the risk of cancers but lowers the risk of coronary disease.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus, Esther van Kleef ... Ben S Cooper
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.

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