2,169 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
  1. Book Review: Bad medicine

    Richard Smith
    In his new book Ben Goldacre argues that the pharmaceutical industry is in poor health and in urgent need of treatment.
  2. Living Science: Crossing oceans

    Eve Marder
    Eve Marder explains why all scientists should spend time living and working in a foreign country.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong, Marc A Suchard, Jesse D Bloom
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele, Cindy Ast ... Wolf B Frommer
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Neuroscience

    Skill learning strengthens cortical representations of motor sequences

    Tobias Wiestler, Jörn Diedrichsen
    Detailed analysis of fMRI data shows that sequences of movements are associated with individual patterns of neural activity that become more distinct with training.
    1. Cell Biology
    2. Neuroscience

    UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans

    Zhitao Hu, Xia-Jing Tong, Joshua M Kaplan
    Long and short variants of a protein called UNC-13, assisted by another called Tomosyn, regulate the timing of synaptic vesicle release in C. elegans.
    1. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble, Zóe Christodoulou ... Mario Recker
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti, Simone Prinz ... John AG Briggs
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.

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