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    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama, Natsuhiko Yoshinaga ... Nobuhide Doi
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Neuroscience

    Cerebellar re-encoding of self-generated head movements

    Guillaume P Dugué, Matthieu Tihy ... Clément Léna
    The cerebellum encodes self-generated head rotations in a head posture-dependent manner, providing in particular a representation of how the head rotates about axes referenced relative to gravity.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnaporthe oryzae

    Xinyu Liu, Qikun Zhou ... Zhengguang Zhang
    A phosphorylation circuitry balancing among kinase, transcription factor, transcription repressor, and phosphatase in response against host immunity during M. oryzae–rice interaction.
    1. Computational and Systems Biology
    2. Neuroscience

    The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

    Marieke MB Hoekstra, Maxime Jan ... Paul Franken
    Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.
    1. Evolutionary Biology
    2. Neuroscience

    The evolution and biological correlates of hand preferences in anthropoid primates

    Kai R Caspar, Fabian Pallasdies ... Sabine Begall
    Primate hand preference strength but not direction (left vs. right) generally reflects phylogeny and ecology at species level, but human handedness deviates markedly from all other species.
    1. Cell Biology
    2. Neuroscience

    HIF1α stabilization in hypoxia is not oxidant-initiated

    Amit Kumar, Manisha Vaish ... Rajiv R Ratan
    The current findings address the redox regulation of hypoxia inducible factor 1α (HIF1α) stability in hypoxia by showing that cytosolic, mitochondrial or lipid ROS are not necessary for HIF1α stabilization in hypoxia.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

    Matthew T Parker, Sebastian M Fica ... Gordon G Simpson
    A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew, Wenming Huang ... Adam Antebi
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

    Tsuyoshi Imasaki, Satoshi Kikkawa ... Ryo Nitta
    CAMSAP2 co-condensates with αβ-tubulin to induce microtubule nucleation and growth, serving as a microtubule-organizing centre for non-centrosomal microtubules.