690 results found
    1. Structural Biology and Molecular Biophysics

    Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    Monarin Uervirojnangkoorn et al.
    Post-refinement methods enable the use of X-ray free electron lasers for biological crystallography of systems in which sample quantity is a limitation.
    1. Structural Biology and Molecular Biophysics

    Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

    Saori Maki-Yonekura et al.
    Crystallography and single particle cryo-EM reveal hexameric and pentameric structures of the ExbBD energizer in the Ton system and oligomeric transition, which provides a unique working mechanism and a new vision of dynamic membrane biology.
    1. Structural Biology and Molecular Biophysics

    The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

    Elin Claesson et al.
    Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and transport mechanism of the sodium/proton antiporter MjNhaP1

    Cristina Paulino et al.
    The inward-open and outward-open structures of MjNhaP1 explain the mechanism of electroneutral sodium-proton antiport across the cell membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a bacterial RNA polymerase holoenzyme open promoter complex

    Brian Bae et al.
    The crystal structure of bacterial RNA polymerase bound to the transcription bubble reveals key features that support the formation of a double-strand/single-strand DNA junction at the upstream edge of the −10 element where bubble formation initiates.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

    Janine Weber et al.
    The crystal structure of Pur-alpha in complex with DNA reveals its molecular mechanisms of nucleic-acid binding and unwinding, allowing for a better understanding of its essential role in neurons.
    1. Structural Biology and Molecular Biophysics

    Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis

    Anusmita Sahoo et al.
    Experimental determination of residue contacts from mutational data allows model discrimination and identification of in vivo functional conformations of proteins.
    1. Structural Biology and Molecular Biophysics

    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

    Stefano Pernigo et al.
    X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase

    Elizabeth C Wittenborn et al.
    Structural analysis reveals large-scale conformational changes in the active site metallocluster of a CO2-fixing enzyme.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

    Kimberley H Gibson et al.
    The corkscrew-like motility of Spirochete bacteria is enabled by a unique, asymmetrically constructed flagellum that wraps around the cell body within the periplasm.

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