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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1

    Yi Ren et al.
    Biochemical and structural analyses of a universal mRNP remodeling pathway suggest an ATPase-powered targeted deposition of export factors onto mRNP.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase

    Elizabeth C Wittenborn et al.
    Structural analysis reveals large-scale conformational changes in the active site metallocluster of a CO2-fixing enzyme.
    1. Structural Biology and Molecular Biophysics

    Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex

    Artem Y Lyubimov et al.
    Building on previous work (Uervirojnangkoorn et al., 2015), we demonstrate how improved methods for processing XFEL diffraction data enable the determination of structures from poorly diffracting crystals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

    Aaron T Bozzi et al.
    Nramp-family transporters adapt a common fold to a novel mechanism in which the spatial and temporal separation of like-charge transition metal and proton co-substrates circumvents the expected electrostatic repulsion.
    1. Structural Biology and Molecular Biophysics

    Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

    Saori Maki-Yonekura et al.
    Crystallography and single particle cryo-EM reveal hexameric and pentameric structures of the ExbBD energizer in the Ton system and oligomeric transition, which provides a unique working mechanism and a new vision of dynamic membrane biology.
    1. Structural Biology and Molecular Biophysics

    A conformational switch regulates the ubiquitin ligase HUWE1

    Bodo Sander et al.
    The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

    Doudou Wang et al.
    The structural and functional analysis demonstrates the mechanism of dual functional, motility and microtubule depolymerization in a unique motor, KIF19A.
    1. Structural Biology and Molecular Biophysics

    Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

    Ivan KH Poon et al.
    A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

    Christina M Zimanyi et al.
    Substrate and effector bound structures of a bacterial ribonucleotide reductase reveal the molecular basis by which substrate preference is modulated by a distal site on the enzyme.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

    Janine Weber et al.
    The crystal structure of Pur-alpha in complex with DNA reveals its molecular mechanisms of nucleic-acid binding and unwinding, allowing for a better understanding of its essential role in neurons.