48 results found
    1. Chromosomes and Gene Expression

    Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring

    Markus P Vallaster et al.
    A novel paternal effect based on nicotine exposure reveals that offspring exhibit an adaptive, yet nonspecific, resistance to multiple toxins.
    1. Microbiology and Infectious Disease

    Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

    Nitzan Koppel et al.
    A unique, widely distributed gut bacterial enzyme selectively metabolizes plant-derived cardiac glycoside drugs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A family of fluoride-specific ion channels with dual-topology architecture

    Randy B Stockbridge et al.
    Efflux of xenobiotic fluoride from microorganisms occurs through a novel family of ion channels with stringent selectivity for fluoride ion and dual-topology molecular architecture.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun et al.
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Cancer Biology
    2. Human Biology and Medicine

    BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

    Naoya Sakamoto et al.
    Genetic analyses reveal how CDX2 and BRAF defects seen in serrated colorectal cancer (CRCs), a poor prognosis CRC subset, cooperate in tumorigenesis in humans and in a mouse cancer model.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Microbiology and Infectious Disease

    Effective use of a horizontally-transferred pathway for dichloromethane catabolism requires post–transfer refinement

    Joshua K Michener et al.
    Adapting bacteria to use an introduced metabolic pathway recapitulates natural mutations and offers a novel bioremediation strategy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

    Blake W Tye et al.
    Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

    John D Chan et al.
    Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malodour precursor transport in the human axilla

    Gurdeep S Minhas et al.
    Discovery of the structural basis for recognition and uptake of a human precursor for body odour production reveals an important role for bacterial peptide transport and novel routes to prevent its production in humans.

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