Measurement of physiological intracellular Ca²⁺ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.

Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.

In pigs, nitrate supplements can protect salivary glands from the damage caused by radiation therapy to the head and neck.

In a mouse model of Sjogren's disease, mitochondrial function and Ca²⁺ signaling are disrupted resulting in altered coupling between Ca²⁺ release and Ca²⁺ activated Cl^- channels and salivary gland hypofunction.

Dietary nitrate supplementation could effectively prevent irradiation therapy-induced xerostomia for patients with head and neck cancer, providing a novel, safe, and effective way to resolve this issue.