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The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance energy transfer experiments, which elucidate the rate-limiting mechanism of MRP1's transport cycle.

A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.

In oligodendrocyte progenitor cells, lipid metabolism and peroxisome biogenesis are regulated by the low-density lipoprotein related-receptor-1, and if disrupted, impair proper white matter development and adult repair.

Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.

Transient expression of Nrp1 is required in postnatal stages for terminal arborization and innervation of secondary areas during the development of somatosensory callosal circuits.

The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.

Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.

Dcp2 C-terminal domain cis-regulatory elements collaborating with specific activators control decapping enzyme targeting and activation by orchestrating sequential assembly of distinct decapping complexes.

Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.

Actr10, a dynactin pointed end protein, is essential for mitochondrial interaction with the dynein-dynactin retrograde motor and subsequent transport.