5,417 results found
    1. Biochemistry and Chemical Biology

    Measurement of average decoding rates of the 61 sense codons in vivo

    Justin Gardin et al.
    The translation rates of each yeast codon have been measured in both the A and P sites of the ribosome.
    1. Structural Biology and Molecular Biophysics

    Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

    Jose Luis Llácer et al.
    The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic et al.
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Cell Biology
    2. Physics of Living Systems

    Metabolic constraints drive self-organization of specialized cell groups

    Sriram Varahan et al.
    In a developing yeast colony, cells go from homogeneous states to spatially organized, specialized metabolic states, and the new metabolic states depend on resources produced by the original state.
    1. Computational and Systems Biology
    2. Neuroscience

    On the dimensionality of odor space

    Markus Meister
    A recent claim that humans can discriminate 1 trillion odors is found to be unwarranted, and further analysis offers insights into the dimensionality of olfactory perception.
    1. Chromosomes and Gene Expression

    The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

    Jyothsna Visweswaraiah et al.
    A structural element of mRNA exit channel protein Rps5 performs a critical role in start codon recognition during translation initiation by stabilizing initiator tRNA binding to the pre-initiation complex.
    1. Cell Biology
    2. Evolutionary Biology

    Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

    Joshua G Dunn et al.
    Ribosomes translate through stop codons far more often than previously thought, yielding C-terminally extended proteins in a variety of eukaryotes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad et al.
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Chromosomes and Gene Expression

    The genetic basis of aneuploidy tolerance in wild yeast

    James Hose et al.
    A single gene allele underlies differences in aneuploidy tolerance in yeast.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Pervasive transcription fine-tunes replication origin activity

    Tito Candelli et al.
    The pervasive transcription environment alters the efficiency of firing of replication origins, which are 'protected' by roadblock termination due to origin recognition complex (ORC) and pre-RC complexes.

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