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    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Computational and Systems Biology
    2. Ecology

    Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels

    Xin Li et al.
    Parallel pathways of xylose metabolism identified in fungi that grow on plants can be used in yeast to promote hemicellulose conversion to biofuels.
    1. Cell Biology

    Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing

    Annina Denoth-Lippuner et al.
    The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi et al.
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells

    Chitra Mohan et al.
    An in vivo disulfide crosslinking assay shows preferential disassembly of nucleosomes with two H2A.Z histones by transcription machinery in yeast and conjugation to one or two ubiquitin moieties in human cells.
    1. Chromosomes and Gene Expression

    High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

    Yi Yin et al.
    Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim et al.
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dosage compensation can buffer copy-number variation in wild yeast

    James Hose et al.
    Dosage-compensated gene expression facilitates chromosomal aneuploidy, which presents a rapid route to phenotypic evolution in natural yeast isolates.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast

    Cihan Erkut et al.
    Roundworms and yeast can survive extreme desiccation only by switching their metabolism into a gluconeogenic mode and producing very high amounts of trehalose via the glyoxylate shunt.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex

    Michael Tramantano et al.
    The transcription machinery is required for the disassembly of the promoter-proximal H2A.Z nucleosome, contributing to the constitutive histone turnover at yeast promoters.