691 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos

    Shai R Joseph et al.
    The relative levels of histones and transcription factors in the nucleus determine transcriptional output in zebrafish embryos.
    1. Cell Biology
    2. Developmental Biology

    In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis

    Fernanda Bajanca et al.
    A multidisciplinary approach was used to translate the mathematical analysis of Dystrophin movements inside muscle cells into the biology of how Dystrophin interacts with the cell membrane.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems biology derived source-sink mechanism of BMP gradient formation

    Joseph Zinski et al.
    Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.
    1. Developmental Biology
    2. Genetics and Genomics

    MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

    Meltem Weger et al.
    The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke et al.
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Computational and Systems Biology
    2. Developmental Biology

    Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain

    Julian Sosnik et al.
    Direct measurements of retinoic acid using fluorescence lifetime imaging reveal a new role for cellular retinoic acid binding proteins in noise attenuation that is critical to sharpen hindbrain rhombomere boundaries.
    1. Cell Biology
    2. Developmental Biology

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong et al.
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
    1. Developmental Biology

    Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

    Tessa G Montague, Alexander F Schier
    Nodal is assumed to be the sole inducer of mesendoderm, but the related signal Vg1 is as essential as Nodal in this process.
    1. Cancer Biology
    2. Developmental Biology

    Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

    Julia Hatzold et al.
    A Na,K-ATPase beta subunit can suppress basal cell carcinogenesis either via its osmoregulatory function to avoid hypotonic stress, or by promoting epithelial polarity and adhesiveness of basal keratinocytes from the overlying outer layer.

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