454 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row et al.
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

    Hiroshi Yamaguchi et al.
    Zebrafish genetics and cryo-electron tomography reveal distinct roles of all vertebrate PIH family proteins in axonemal dynein assembly and cilia/flagella motions, assigning specific dynein subtypes to each PIH protein.
    1. Cell Biology
    2. Developmental Biology

    Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure

    Ian A Swinburne et al.
    The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.
    1. Cell Biology
    2. Developmental Biology

    A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

    Maria L Spletter et al.
    A developmental transcriptomics resource from Drosophila flight muscles quantifies the transcriptional dynamics during muscle morphogenesis and identifies three ordered phases of sarcomere morphogenesis.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Neuroscience

    Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

    Eliot Dow et al.
    The technique of serial blockface scanning electron microscopy, which permits the complete reconstruction of neuronal structures, allows comparison of the detailed "wiring diagrams" of lateral-line receptor organs in wild-type and mutant zebrafish.
    1. Developmental Biology

    Chiral cell sliding drives left-right asymmetric organ twisting

    Mikiko Inaki et al.
    Left-right asymmetric rotation of the Drosophila hindgut is driven by "cell sliding," a novel cellular behavior induced by chiral cell deformation, in which cells change their position relative to subjacent neighbors as sliding directionally.

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