616 results found
    1. Cell Biology

    Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle

    Maria N Lo, Leah J Damon ... Amy E Palmer
    Zinc affects the proliferation-quiescence cell fate decision of mammalian cells, demonstrating that micronutrients can regulate the cell cycle.
    1. Plant Biology

    LPCAT1 controls phosphate homeostasis in a zinc-dependent manner

    Mushtak Kisko, Nadia Bouain ... Hatem Rouached
    Phosphate accumulation in zinc-deficient Arabidobsis shoots is regulated by a pathway involving the transcription factor bZIP23, the phospholipid-remodelling enzyme LPCAT1 and the transporter PHT1;1.
    1. Medicine

    The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

    Pinanong Na-Phatthalung, Shumin Sun ... Fudi Wang
    Zinc transporter Slc30a1 mediates antibacterial defense in macrophages.
    1. Structural Biology and Molecular Biophysics

    The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

    Achinta Sannigrahi, Sourav Chowdhury ... Krishnananda Chattopadhyay
    How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
    1. Cell Biology

    The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

    Guiran Xiao, Zhihui Wan ... Bing Zhou
    Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra, Jacob McArthy ... Victor Faundez
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Cell Biology
    2. Developmental Biology

    Zn2+ is essential for Ca2+ oscillations in mouse eggs

    Hiroki Akizawa, Emily M Lopes, Rafael A Fissore
    Throughout oocyte maturation, there is a simultaneous elevation in the concentrations of Ca2+ and Zn2+, and the fertilization-induced Ca2+ oscillations cease under Zn2+-deficient conditions, implying an interplay between these ions, potentially at the IP3R1 level that harbors a Zn2+-binding domain.
    1. Ecology
    2. Epidemiology and Global Health

    Hidden shift of the ionome of plants exposed to elevated CO2 depletes minerals at the base of human nutrition

    Irakli Loladze
    Increasing levels of atmospheric carbon dioxide reduce the mineral content but increase the levels of starch and sugars found in crop plants; which could exacerbate both obesity and malnutrition in some human populations.
    1. Cell Biology
    2. Immunology and Inflammation

    Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

    Xin Wang, Anjun Jiao ... Baojun Zhang
    Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

    Robert LeDesma, Brigitte Heller ... Alexander Ploss
    A combined computational, genetic, and biochemical analysis of the hepatitis E virus open reading frame 1 (ORF1) protein identifies a novel domain-domain interaction that is vital for fitness and supports a proposed structural model of the ORF1 polyprotein.

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