A new component, CatSper zeta, is required for continuous alignment of the calcium channel along the sperm's tail and is crucial for normal sperm swimming behavior and fertility.
Newly prepared double gene-edited sheep provide excellent models for skeletal muscle growth and development, and muscle diseases such as muscle atrophy and sarcopenia.
Iromi Wanigasuriya, Quentin Gouil ... Marnie E Blewitt
Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.
Sarah Jacquelyn Smith, Lance A Davidson, Mark Rebeiz
A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
Kirsty ML Mackinlay, Bailey AT Weatherbee ... Magdalena Zernicka-Goetz
Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.
