10,420 results found
    1. Neuroscience

    Leave-One-Trial-Out, LOTO, a general approach to link single-trial parameters of cognitive models to neural data

    Sebastian Gluth, Nachshon Meiran
    Leave-One-Trial-Out (LOTO) is a general, efficient and easily implementable approach for inferring trial-by-trial measures of computational model parameters in order to link these measures to neural mechanisms.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

    Yoko Ogawa et al.
    PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.
    1. Neuroscience

    Serial grouping of 2D-image regions with object-based attention in humans

    Danique Jeurissen et al.
    The human visual system groups the individual features of objects together into a coherent whole via a serial, attention-demanding process.
    1. Cell Biology

    Spatial signals link exit from mitosis to spindle position

    Jill Elaine Falk et al.
    In yeast, exit from mitosis is triggered by the movement of one spindle pole body out of the mother cell into the bud, the future daughter cell.
    1. Medicine
    2. Neuroscience

    AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

    Yunlu Xue et al.
    AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo et al.
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Uniparental nuclear inheritance following bisexual mating in fungi

    Vikas Yadav et al.
    Discovery of a novel mode of sexual reproduction, termed pseudosexual reproduction, in fungi where both parents are required for mating but only one contributes to the meiotic progeny, similar to hybridogenesis in animals.
    1. Neuroscience

    Image content is more important than Bouma’s Law for scene metamers

    Thomas SA Wallis et al.
    Peripheral appearance models emphasising pooling processes that depend on retinal eccentricity will instead need to explore input-dependent grouping and segmentation.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Many-molecule encapsulation by an icosahedral shell

    Jason D Perlmutter et al.
    Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.
    1. Medicine
    2. Neuroscience

    Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics

    Ming Song et al.
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.

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