3,456 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.
    1. Biochemistry and Chemical Biology

    Ctf4 organizes sister replisomes and Pol α into a replication factory

    Zuanning Yuan et al.
    Eukaryotic replisomes are strongly connected together to replicate both sister DNAs produced from a bidirectional origin.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

    Benson Ogunjimi et al.
    An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.
    1. Chromosomes and Gene Expression

    MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

    Ge Zheng et al.
    Systematic analyses of DNA replication machinery components in human cells reveal a requirement of MCM-dependent de novo loading or mobilization of cohesin at replication forks in establishing sister-chromatid cohesion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

    Vladimir A Volkov et al.
    Multiple NDC80 complexes in the outer kinetochore cooperate to bind the ends of depolymerizing microtubules and harness their power stroke.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Direct live imaging of cell–cell protein transfer by transient outer membrane fusion in Myxococcus xanthus

    Adrien Ducret et al.
    Physical contact between two Myxococcus xanthus cells is sufficient to fuse their outer membrane transiently and exchange outer membrane proteins and lipids at high efficiency.
    1. Cell Biology

    Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching

    Nigel J Burroughs et al.
    Directional switching of sister chromatids during mitosis is regulated by a mechanical clock that is sensitive to the stretch of centromeric chromatin between the chromatids.
    1. Physics of Living Systems
    2. Cell Biology

    Physical basis of large microtubule aster growth

    Keisuke Ishihara et al.
    Autocatalytic growth of a microtubule polymer network allows extremely large egg cells to self-organize and divide rapidly.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagellar capping proteins adopt diverse oligomeric states

    Sandra Postel et al.
    The first high-resolution structure of a bacterial flagellar cap protein, FliD, reveals new insights into the assembly of bacterial flagella.

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