251 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

    Young Sun Hwang et al.
    In Aves, the first wave of transcription is derived exclusively from the maternal genome.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin et al.
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
    1. Developmental Biology
    2. Genetics and Genomics

    Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

    Xiao-Yong Li et al.
    Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
    1. Developmental Biology

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Yun Huang et al.
    Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos

    Shai R Joseph et al.
    The relative levels of histones and transcription factors in the nucleus determine transcriptional output in zebrafish embryos.
    1. Stem Cells and Regenerative Medicine

    Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

    Yixuan Wang et al.
    During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    A global change in RNA polymerase II pausing during the Drosophila midblastula transition

    Kai Chen et al.
    The first zygotic genes are transcribed without RNA polymerase II pausing from a TATA-enriched promoter.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang et al.
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink et al.
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.

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