Browse our latest Biochemistry and Chemical Biology articles

Four conserved ciliary localization signals in the Joubert syndrome-associated INPP5E phosphoinositide phosphatase control its ciliary accumulation.

The yeast U1 snRNP recognizes multiple features of target RNAs to reversibly identify splicing-competent 5' splice sites.

Structural basis and molecular mechanism of how molecular chaperone Hsp27 specifically captures phosphorylated Tau and prevents it from abnormal aggregation.

Structure of M. tuberculosis Rv1625c/Cya provides clues to the potential functional role of the transmembrane domain in the membrane adenylyl cyclases.

The crystal structure of a mammalian protein kinase G reveals contacts between the regulatory and catalytic domains, indicates how cGMP binding alters domain conformations and thus domain:domain interactions, and informs a model for enzyme auto-inhibition and cooperative activation.

Structural and biochemical analysis of semisynthetic Akt forms and mutants has revealed the importance of a key interaction network involving Arg86, Glu17, and Tyr18 that controls Akt conformation and activity.

The coupling of the enzyme/structure core to different short linear motifs represents a novel mechanism to diversify and expand the function of signaling proteins.

UBX proteins reduce the ubiquitin threshold of mammalian p97-UFD1-NPL4.

An array of cytosolic co-chaperones and chaperones helps to maintain newly synthesized mitochondrial outer membrane proteins in an import competent state.

DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.