Browse our latest Biophysics and Structural Biology articles

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    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

    Inna Rozman Grinberg et al.
    Structural and functional characterization of an unanticipated mode of allosteric activity regulation in ribonucleotide reductases controlled by an ATP-cone in the radical-generating subunit.
    1. Biophysics and Structural Biology
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee et al.
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Biophysics and Structural Biology
    2. Human Biology and Medicine

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner et al.
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.
    1. Biophysics and Structural Biology

    Structure-based membrane dome mechanism for Piezo mechanosensitivity

    Yusong R Guo, Roderick MacKinnon
    Mechanosensitive Piezo channel induces local membrane curvature to mediate mechanical gating.
    1. Biophysics and Structural Biology
    2. Neuroscience

    Piezo Ion Channels: Portraits of a pressure sensor

    Alexander T Chesler, Marcin Szczot
    Near atomic-resolution structures have provided insights into the mechanisms by which the Piezo1 ion channel senses and responds to mechanical stimuli.
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    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Prediction of enzymatic pathways by integrative pathway mapping

    Sara Calhoun et al.
    A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis

    Tetsuya Takeda et al.
    A new approach using combination of electron microscopy (EM) and high-speed atomic force microscopy (HS-AFM) clearly demonstrates dynamics of dynamin-amphiphysin complexes during membrane constriction and fission suggesting a novel 'clusterase' model of the dynamin-mediated membrane fission.