Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

    Daiki Kato et al.
    The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
    1. Cancer Biology
    2. Cell Biology

    Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

    Simranjot Bawa et al.
    TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
    1. Cancer Biology
    2. Physics of Living Systems

    Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

    Debanjan Goswami et al.
    Compared to other isoforms of RAS, KRAS4b has unique membrane diffusion behavior related to its biology, and the two major domains of the protein both contribute to this diffusion behavior.
    1. Cancer Biology

    Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

    Francesca Maria Bosisio et al.
    Multiplexing and digital analysis of melanoma tissue describe functionally the microenvironment associated with brisk/non-brisk infiltrates and expose the functional incongruences of this morphological classification currently in use for tumor-infiltrating lymphocytes.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

    Ana Filipa Domingues et al.
    Histone acetyl-transferase Kat2a preserves leukemia stem cells through frequent transcriptional firing of metabolic and regulatory gene promoters and maintenance of a largely invariant self-renewal program.
    1. Cancer Biology
    2. Cell Biology

    Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

    Helena Brezovjakova et al.
    Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
    1. Cancer Biology

    Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

    Ana Rita Pombo Antunes et al.
    The heterogeneity of immune cell types in glioblastoma tumors depends on the tumor's genetic make-up and treatment status and is an incompletely mined source of novel therapeutic targets.

Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Maureen Murphy
    The Wistar Institute, United States
  4. See more editors