Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Developmental Biology

    E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

    Maria Paula Zappia et al.
    The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.
    1. Cancer Biology

    An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

    Polona Safaric Tepes et al.
    Erlotinib-resistant AXL overexpressing cells are present in therapy-naive tumors, and expression of AXL in these cells is regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335.
    1. Cancer Biology

    Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

    Nicolai J Toft et al.
    Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

    Madeleine Bossaert et al.
    Topoisomerase 2α DNA breaks induced by G-quadruplex ligands are associated with a topological stress resulting from a transcription-dependent mechanism and counteracted by DNA topoisomerase 1 and factors promoting transcription elongation.
    1. Cancer Biology
    2. Cell Biology

    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

    Kerrie-Ann McMahon et al.
    Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.
    1. Cancer Biology

    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

    Haritha Mathsyaraja et al.
    The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
    1. Cancer Biology

    Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

    Qiaoling Liu et al.
    EXOSC1 acts as an endogenous source of mutation inkidney renalclear cell carcinoma via cleaving single-stranded DNA.
    1. Cancer Biology

    Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

    Ophir Shani et al.
    Metastases-associated fibroblasts show stage-dependent transcriptional plasticity and their rewiring is regulated by Myc.
    1. Cancer Biology
    2. Cell Biology

    A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

    Jesusa Capera et al.
    The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.

Senior editors

  1. Wafik S El-Deiry
    Brown University, United States
  2. Erica Golemis
    Fox Chase Cancer Center, United States
  3. Maureen Murphy
    The Wistar Institute, United States
  4. See more editors